Warning needs to be exercised when administering Promethazine to pediatric individuals 2 years of age and more mature. It is recommended that the bottom efficient dose of Promethazine be used in pediatric people 2 decades of age and older and concomitant administration of other medicine with respiratory depressant results be avoided. WARNINGS
Excessively substantial dosages of antihistamines, including promethazine hydrochloride, in pediatric individuals may possibly bring about unexpected Dying (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric people. In pediatric people who will be acutely sick associated with dehydration, You can find a heightened susceptibility to dystonias with using promethazine HCl.
Opioids are sought by drug abusers and individuals with habit Issues and therefore are subject to legal diversion. Think about these risks when prescribing or dispensing Promethazine HCl and Codeine Phosphate Oral Alternative. Strategies to cut back these pitfalls include things like prescribing the drug in the smallest correct amount and advising the client on the correct disposal of unused drug [see Affected person Counseling Facts (seventeen)].
Impaired secretion from sweat glands following harmful doses of prescription drugs with anticholinergic Unwanted side effects might predispose to hyperthermia.
Unique scientific tests to test the motion on the drug on parturition, lactation, and progress of the animal neonate were not finished, but a common preliminary study in rats indicated no effect on these parameters.
Promethazine Promethazine is usually a phenothiazine spinoff, which differs structurally within the antipsychotic phenothiazines from the existence of the branched side chain and no ring substitution.
g., These with evidence of improved intracranial strain or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Option may possibly decrease respiratory push, plus the resultant CO2 retention can even further raise intracranial force. Also, opioids develop adverse reactions that could obscure the clinical training course of individuals with head accidents.
Excessively huge dosages of antihistamines, including Promethazine HCl Oral Solution, in pediatric patients may perhaps lead to sudden Demise (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of Promethazine in pediatric patients. In pediatric patients who're acutely sick associated with dehydration, There exists an elevated susceptibility to dystonias with using Promethazine HCl.
Acute or severe bronchial asthma within an unmonitored location or in absence of resuscitative machines. (four)
Promethazine HCl happens as a white to faint yellow, pretty much odorless, crystalline powder which slowly oxidizes and turns blue on prolonged publicity to air. It's freely soluble in h2o and soluble in Liquor.
Limited data recommend that use of promethazine hydrochloride during labor and supply does click here not have an appreciable impact on the period of labor or supply and would not enhance the chance of will need for intervention from the newborn.
Promethazine is metabolized via the liver to several different compounds; the sulfoxides of Promethazine and N-demethylpromethazine are definitely the predominant metabolites appearing in the urine.
The standard efficient dose of Promethazine HCl Oral Answer with the active therapy of nausea and vomiting in kids or Grownups is twenty five mg.
Promethazine is effectively absorbed within the gastrointestinal tract. Scientific outcomes are obvious inside 20 minutes just after oral administration and generally past four to six several hours, although They could persist assuming that 12 hrs.